And those antioxidants? Although researchers have yet to determine the exact mechanisms behind some of the disease-preventing effects, it is important to keep in mind that these compounds may be exerting other beneficial effects, such as acting as an anti-inflammatory. Coffee also contains small amounts of some nutrients, including potassium, niacin and magnesium.
Bladder and pancreatic cancer. Studies performed more than 30 years ago suggested a potential link between coffee consumption and cancers of the bladder, pancreas, and possibly others. Since then, better research has largely refuted these concerns. In fact, some of the older studies raising red flags about a cancer link have since been used as examples of “fishing expeditions” and weak research methodology.
“For example, prior studies have suggested that variants in CYP1A2, (a gene) encoding the enzyme responsible for more than 95 percent of caffeine metabolism, may alter associations of coffee drinking with cardiovascular-related outcomes, with slower caffeine metabolizers having higher risk of developing hypertension (high blood pressure) or having a myocardial infarction (heart attack) relative to their non-drinking counterparts, whereas faster caffeine metabolizers who drink coffee are at no or lower risk of these outcomes.”
After the researchers induced myocardial infarction in the mice during their experiments, the extra stores of p27 in the caffeinated cells apparently prevented damaged heart muscle cells from dying. The paper says the mitochondrial p27 also triggered the creation of cells armed with strong fibers to withstand mechanical forces, and promoted repairs to the linings of blood vessels and the inner chambers of the heart. To confirm the protein’s importance, the scientists engineered mice with a p27 deficiency. Those mice were found to have impaired mitochondrial function that did not improve with caffeine.

Other studies have tried to tease apart which ingredients in coffee contribute to its health benefits. Those might include its antioxidants, which can combat cancer, and anti-inflammatory compounds, which can reduce the risk of chronic diseases such as heart conditions and even neurodegenerative disorders like Alzheimer’s, as well as the risk of liver diseases like cirrhosis and cancer. 

There’s no need to try anything crazy; the only performance enhancer you really need is coffee. Research has shown its ability to give workouts a boost and increase athletic performance, and that’s exactly why you’ll find so many Olympians drinking it: One report from the journal Applied Physiology, Nutrition, and Metabolism found the majority of the 20,686 Olympic athletes analyzed had caffeine in their urine.
Diabetes is on the upswing in the United States: About 1.5 million people are diagnosed each year, according to the American Diabetes Association, and approximately 7.2 million people have the disease but don’t know it yet. But it's not all bad news. Researchers from Harvard University believe that drinking coffee—either decaf or regular—might help prevent the development of type 2 diabetes, the most common form. According to the analysis, which was published in the journal Diabetes Care, the more coffee people drink, the less likely they are to develop type 2 diabetes. (It is possible to overdo it, though. To keep insomnia, tummy troubles, and migraines at bay, health experts recommend drinking no more than four 8-ounce coffees daily.)
In the Hungry For Change Book we discuss the addictive nature of caffeine and when consumed in large quantities, can lead to adrenal fatigue. Coffee is also a diuretic, meaning it purges water from your body. That said, if you want to function at a high level and remain well hydrated, then it would be a better choice to replace coffee with a natural alternative. The list below provides some great tasting substitutes.

Malignant melanomas are the most dangerous and potentially life-threatening form of skin cancer and one of the most common cancer types in the United States. Studies have found that there is potentially as much as a 20 percent lower risk when a person drinks a minimum of four cups of coffee daily. The type of coffee matters here, as the study showed that decaffeinated coffee was not as effective. Studies on non-melanoma cancer and coffee have shown that people were 17 percent less likely to develop the most common form of skin cancer, basal cell carcinoma, if they drank three or more cups of coffee daily.